A simple, accurate and precise U.V spectrophotometric method has been developed and validated for the simultaneous estimation of Febuxostat and Diclofenac Potassium in combined dosage form by using Acetonitrile. The absorption maxima of Febuxostat and Diclofenac Potassium were found to be 314nm and 282nm. Linearity ranges of Febuxostat and Diclofenac Potassium were found to be 10-100�µg/ml and 25-150�µg/ml with correlation coefficients (r2) of the regression equations greater than 0.999 in all cases respectively. LOD and LOQ for Febuxostat and Diclofenac Potassium were found to be 0.73ug/ml & 1.09ug/ml and 2.2ug/ml & 3.3ug/ml respectively. Results of assay and recovery studies were statistically evaluated for its accuracy and precision in all cases. According to the validation results performed as per ICH guidelines, the proposed method was found to be specific, accurate, precise and could be applied to the simultaneous quantitative analysis of Febuxostat and Diclofenac Potassium.
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